Jan 28, 2016, 11:24 PM
News Code: 81939887
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Scientists crack what causes schizophrenia

Tehran, Jan 28, IRNA – A game-changing study described as a 'turning point' in tackling mental illness has revealed the biological cause of schizophrenia, Mail Online health news reported.

For the first time, scientists have linked the devastating disease to a physical process, the 'pruning' of unwanted connections between brain neurons.
They hope the discovery will lead to more effective treatments targeting the disorder's roots rather than its symptoms.
During the teenage years, the brain undergoes widespread re-wiring that involves 'synaptic pruning'.
The new study, based on a genetic analysis of nearly 65,000 people from around the world, pinpointed a defective gene that appears to trigger excessive pruning.
Scientists believe it is this that underlies the symptoms of schizophrenia, a severe psychotic condition marked by a loosening grip on reality, delusions, paranoia and hallucinations.
They hope the discovery will lead to more effective treatments targeting the disorder's roots rather than its symptoms.
During adolescence, the brain undergoes widespread re-wiring that involves 'synaptic pruning'.
Schizophrenia affects more than 21 million people worldwide and typically begins in late adolescence or early adulthood. Half of people living with schizophrenia do not receive care for the condition, according to the World Health Organization, WHO.
However, even when they do, existing drugs don't get to the root of the illness and there have been few advances in the last 50 years. Lead researcher Dr Steven McCarroll, from Harvard Medical School in, said: 'Since schizophrenia was first described over a century ago, its underlying biology has been a black box, in part because it has been virtually impossible to model the disorder in cells or animals.
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